01)。PDGF诱导的ERK、JNK和p38活性均在2min时迅速增高,分别在2～5min达高峰,分别为基础水平的5.7倍、2.6倍和1.6倍(P<0.05),ERK和JNK活性增高可持续至120min,而p38活性则于60min以后恢复至基础水平。在PDGF刺激24h的情况下,PD98059和SP600125不影响基础状态及PDGF对α-SMA表达的作用,但SP600125可抑制PDGF上调的细胞移行能力(P<0.01);而SB203580既可抑制α-SMA的基础表达(P<0.01)及PDGF下调的α-SMA表达(P<0.001),同时还可显著抑制PDGF诱导的细胞移行能力(P<0.05)。结论PDGF可刺?
AIM: 也许 To

investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (icv) of interleukin-1β (IL-1β) or footshock. METHODS: We examined the effects of p38 MAPK on mean artery blood pressure (mABP), heart rate (HR), and motor activity (MA) during central administration of IL-1β, or footshock after icv SB203580 (a specific inhibitor of the p38 MAPK) with Cardiovascular and Behavior Telemetry

System in conscious SD rats. RESULTS: (1) IL-1β (icv) or footshock remarkably rise the mABP, AC220研究购买 and the maximal changes are (7.8±1.8) and (12.3±3.5) mmHg, respectively, which was abrogated by the pretreatment with p38 inhibitor SB203580 intracerebroventricularly. (2) Compared with icv saline group, the motor activity was significantly decreased in SB203580 group with maximal changes (-7.6±1.1) counts/min after footshock. CONCLUSION: p38 MAPK plays an important role in the pres- sor response induced by central administration of IL-1β or footshock and change of motor activity after footshock in conscious 已经 rats.
A Review The diseases caused by endotoxin

have seriously affected human health. Previous studies have shown that p38 MAPK pathway is involved in the intracellular signal transduction induced by lipopolysaccharide (LPS), which plays an important role in the activation of inflammation-related cells to release inflammation mediator. Recently there have been some progresses in the isoforms distribution, substrate, molecular mechanism of regulating the release of inflammatory mediators, cellular specific activation and levels of p38 MAPK. [
Shock waves were elicited by transient pressure disturbances, which could be used to treat musculoskeletal disorders.